Immune tolerance is a state of immune unresponsiveness or non-reactivity to certain antigens, which are typically harmless or self-proteins. This is an important mechanism for preventing the immune system from attacking the body's own tissues and causing autoimmune diseases. Research in immune tolerance focuses on understanding the mechanisms that underlie this process, as well as developing therapeutic approaches to induce or restore immune tolerance in individuals with autoimmune disorders. This can involve strategies such as antigen-specific immunotherapy, regulatory T cell therapy, and the use of tolerogenic dendritic cells. Overall, the goal of research in immune tolerance is to create treatments that can modulate the immune system in a targeted manner to prevent harmful immune responses while maintaining the ability to fight off infections and other threats.